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- Tom HanksTom Hanks's wife, Rita WilsonRita Wilson, saw the play and recommended that her husband produce a movie version. In an interview with the German magazine "Cinema", Nia VardalosNia Vardalos mentioned that she hung up when Hanks called, because she didn't believe it was really him.
- Nia VardalosNia Vardalos's real-life husband, Ian GomezIan Gomez, plays Ian's best friend, Mike.
- The song playing at the wedding reception, "All My Only Dreams", first appeared in That Thing You Do! which was written, directed, and produced by Tom HanksTom Hanks, who also produced this film.
- The scene where Andrea MartinAndrea Martin playfully grabs John CorbettJohn Corbett's hair was ad-libbed; Martin had forgotten her lines, played with Corbett's hair (to which Corbett stayed in character and played along), remembered her lines and continued. Nia VardalosNia Vardalos said that it worked out so well they decided to print the take and use it.
- According to Nia VardalosNia Vardalos, paying for catering during the film proved not to be a problem. Wherever the film was being shot, whenever local Greek restaurants learned about it, they sent over lots of free food.
- Despite its status as a small independent film, and despite never holding the number one spot at the American box office, the movie went on to earn almost US$369 million, a return of over sixty-one times (6150%) its US$6 million (inflation-adjusted) budget. For that reason, it is the second most profitable film of all time after Paranormal Activity. That film returned 12890 times the money invested (1289038.67%) with a budget of $15000. The Worlwide Box Office stopped ringing in $193m.
- Toula is seen at work booking a trip for "Doreen Christakos." That is the name of Nia VardalosNia Vardalos' mother.
- When Andrea MartinAndrea Martin's character learns that John CorbettJohn Corbett's character is a vegetarian, she gets a bewildered look and replies, "That's okay. I make lamb." Nia VardalosNia Vardalos said this reflects the confusion that many Greeks have toward vegetarianism. During World War II, food was scarce, so Greeks subsisted on anything available. To them, it makes little sense not to eat meat.
- The opening scene where Nia VardalosNia Vardalos and Michael ConstantineMichael Constantine travel in the early morning to open the restaurant was one of the very last scenes filled. Vardalos said that all of the other cast members had finished their scenes and had left, and so the sadness she and Constantine had in that car scene reflected the tearful goodbyes they'd said.
- In the movie poster, the two E's in the word "Greek" are made to look like the Greek letter Sigma, which is S, not E. To a Greek, it reads "My Big Fat Grssk Wedding".
- At the wedding reception, no one was doing the dance correctly. The cast was too tired.
- All the people in the bride's side at the wedding are all members of Nia VardalosNia Vardalos' family.
- In the fall of 2002 the film surpassed Dances with Wolves as the highest grossing movie never to have hit number one at the weekend box office. By the weekend of October 4-6, it surpassed The Blair Witch Project as the highest-grossing independent film of all time, until March 2004, when it was surpassed by The Passion of the Christ. Theatres continued to run the film after its initial video release.