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Select Guest Cast
Beth Behrs => Nell (The Separation Triangulation)
Walton Goggins => Oliver (The Separation Triangulation)
Bill Gates => Bill Gates (The Gates Excitation)
Bob Newhart => Arthur Jeffries (The Proton Regeneration)
Pamela Adlon => Halley Wolowitz (voice) (The Proton Regeneration)
Brian George => Dr. V.M. Koothrappali (The Confidence Erosion)
Brian Thomas Smith => Zack Johnson (The Bitcoin Entanglement)
Carol Ann Susi => Debbie Wolowitz (voice) (The Bitcoin Entanglement)
Chelsea Hamill => Wedding Guest in Red Dress (The Bow Tie Asymmetry)
Courtney Henggeler => Missy Cooper (The Bow Tie Asymmetry)
Kathy Bates => Mrs. Fowler (The Bow Tie Asymmetry)
Mark Hamill => Mark Hamill (The Bow Tie Asymmetry)
Teller => Larry Fowler (The Bow Tie Asymmetry)
Dana L. Wilson => Dr. Sanders (The Explosion Implosion)
Michael Patrick McGill => Police Officer (The Explosion Implosion)
Dean Norris => Colonel Richard Williams (The Tesla Recoil)
George Wyner => Dr. Zane (The Proposal Proposal)
Riki Lindhome => Ramona Nowitzki (The Proposal Proposal)
Stephen Hawking => Stephen Hawking (The Proposal Proposal)
Susan Chuang => Dr. Harris (The Proposal Proposal)
Ira Flatow => Ira Flatow (The Retraction Reaction)
Regina King => Janine Davis (The Retraction Reaction)
Jerry O'Connell => George Cooper, Jr. (The Sibling Realignment)
Joshua Malina => President Siebert (The Monetary Insufficiency)
Mark Berry => Pit Boss (The Monetary Insufficiency)
Lauren Lapkus => Denise (The Comet Polarization)
Neil Gaiman => Neil Gaiman (The Comet Polarization)
Michelle Arthur => Mrs. Petrescu (The Tenant Disassociation)
Peter MacNicol => Dr. Robert Wolcott (The Reclusive Potential)
Swati Kapila => Ruchi (The Relaxation Integration)
Select Cast and Crew
Anthony Rich => Director
Gay Linvill => Director
Mark Cendrowski => Director
Nicole Lorre => Director
Adam Faberman => Writer
Andrew Gordon => Writer
Anthony Del Broccolo => Writer
David Goetsch => Writer
Eric Kaplan => Writer
Jeremy Howe => Writer
Maria Ferrari => Writer
Steve Holland => Writer
Steven Molaro => Writer
Tara Hernandez => Writer
Barenaked Ladies => Songs
Bill Prady => Creator
Chuck Lorre => Creator
Brian Posehn => Bert Kibbler
Christine Baranski => Dr. Beverly Hofstadter
Jim Parsons => Sheldon Cooper
John Ross Bowie => Barry Kripke
Johnny Galecki => Leonard Hofstadter
Kaley Cuoco => Penny Hofstadter
Kevin Sussman => Stuart Bloom
Kunal Nayyar => Raj Koothrappali
Laurie Metcalf => Mary Cooper
Mayim Bialik => Amy Farrah Fowler
Melissa Rauch => Bernadette Rostenkowski
Simon Helberg => Howard Wolowitz
Wil Wheaton => Wil Wheaton

Random Trivia For This Title:

  • The Bow Tie Asymmetry: In a deleted closing scene, Sheldon and Amy open wedding gifts and are overcome when they receive a pocket watch from Stephen Hawking, who had mailed it to Leonard's address some time before his death. Hawking jokingly engraves on the watch that it was "about time" Sheldon and Amy got married. The scene ends with a still shot of Hawking with the cast and crew as a tribute.
  • The Bow Tie Asymmetry: Laurie Metcalf and Jerry O'Connell were both also in Scream 2 (1997) together.
  • The Bow Tie Asymmetry: Courtney Henggeler was actually pregnant in real life at the time of the taping of this episode.
  • The Bow Tie Asymmetry: Mark Hamill does have a dog in real life, but it is not the dog used. His actual dog, who's named Millie and not Bark, was not allowed to be used per union rules. Therefore he used an acting dog, and made up the idea of the fans naming his dog online as for why it's named as such.
  • The Bow Tie Asymmetry: Director Mark Cendrowski was the beneficiary of a new rule instituted for the 2018 Emmy Awards. The new rule requires that at least one multi-camera show be nominated in the category of Outstanding Directing for a Comedy Series. This episode was the top vote-getter among multi-camera submissions, so Cendrowski was nominated. This was the show's first nomination in this category.
  • The Bow Tie Asymmetry: Wil Wheaton's real wife is seated next to him.
  • The Bow Tie Asymmetry: Kathy Bates and Laurie Metcalf both portrayed Annie Wilkes in Stephen King's Misery. Bates portrayed her on film, while Metcalf portrayed her on the 2015 Broadway production.
  • The Bow Tie Asymmetry: Mayim Bialik claims she didn't feel "beautiful" wearing the wedding dress. This reminded her of her own marriage, which resulted in a divorce.
  • The Bow Tie Asymmetry: The running gag of people talking to Mr. Fowler, only for Mrs. Fowler to cut him off before he can speak, is an in-joke to Teller's magic/comedy act with Penn Jillette; Jillette is the more loquacious of the two, and Teller rarely, if ever, speaks. His silence stems from his youth when he performed at college frat parties; he found that by refraining from speaking, the audience was less likely to heckle him and more likely to pay attention to his act. In this episode he says "thank you" to Penny, marking an extremely rare occurrence of him speaking on film.
  • The Bow Tie Asymmetry: According to the producers, the role of Amy's father Larry was not written with the plan or idea of Teller playing the part. It was only upon the script's being finalized when the producers realized that Teller would be the perfect person for the part.
  • The Tesla Recoil: It's stated that Edison electrocuted an elephant named Topsy. The elephant was already slated for execution, but animal groups disliked the hanging method that was going to be used. Topsy was fed cyanid laced carrots, and had a noose in addition to being hit with 6600 volts. Edison's company produced the 74 second film, but it was her owners that ordered her death, not Edison.
  • The Proposal Proposal: Bernadette is pregnant again because Melissa Rauch is pregnant in real life.
  • The Proton Regeneration: Behind Wil Wheaton, a model of a [Star Wars] speeder bike with scout trooper figure is visible. This reflects Wheaton's enthusiasm for the [Star Wars] franchise, which predates his role on [Star Trek], and counters his taunt of the [Star Wars] moviegoers in [The Big Bang Theory: The Opening Night Excitation (2015)].
  • The Collaboration Contamination: After Penny is able to calm down Sheldon, Leonard asks her if she is a witch. This may be a tip of the "witch's" hat to the character Kaley played in the final season of [Charmed (1998)]. A young and powerful new witch named Billie Jenkins.