Random Trivia For This Title:
- When Juni and Grandpa emerge from the game, Grandpa says that the armrests on his wheelchair are covered in rich Corinthian leather. This is a reference to actor Ricardo Montalban's Chrysler Cordoba television commercials in the late '70's ("The seats are upholstered in rich Corinthian leather").
- When Juni is entering the next level of the video game, he comes across a place named "Rebel Rockets" the names of director Robert Rodriguez's two sons.
- George Clooney's scenes were shot in one afternoon in his own living room. He shot the scenes in a suit jacket, shirt, tie and pajama pants.
- Sylvester Stallone said in an interview that he asked his kids about the previous Spy Kids movies and if he should accept the role in the third installment.
- Due to filming schedules, many of the actors playing characters in the final scene were never on the set at the same time and were put together digitally.
- In Italy, for the theatrical release, the film was renamed simply Missione 3D: Game Over (3D Mission: Game Over), without any references in the trailers, or anywhere else, of it being a part of the [Spy Kids] trilogy.
- Final live-action film appearance of Ricardo Montalban.