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- Robert RodriguezRobert Rodriguez directed scenes of "Stab," the movie-within-a-movie of Scream 2. Rodriguez directed the Casey Becker scene and the Sidney and Billy scene.
- Body count: 10. They go as follows: Phil Stevens, Maureen Evans, Cici, Randy, Bodyguard 1, Bodyguard 2, Hallie, Derek, Mrs. Loomis (2nd Killer) (it is revealed that she killed Randy), Mickey (1st Killer).
- Jada Pinkett SmithJada Pinkett Smith's character complains, "The horror genre is historical for excluding African-American elements." Pinkett played a strong character in Tales from the Crypt: Demon Knight.
- The scene of "Stab," the movie-within-a-movie of Scream 2, that recreates Casey Becker's death also recreates, and exaggerates, an apparent error of Scream. In Scream Casey (Drew BarrymoreDrew Barrymore) was stabbed in the chest with an obviously prop, retractable knife, and the wound did not bleed until the shot following the stabbing in which Casey falls to the ground. When Casey (Heather GrahamHeather Graham) is stabbed in "Stab," the knife almost leaves her chest, revealing the sweater undamaged.
- Kevin WilliamsonKevin Williamson had the idea for a sequel while writing the script for Scream, discovering there was more to the story. Scream 2 began principal photography just six months after the release of Scream; and it was released less than a year after its predecessor.
- A number of sequences in Kevin WilliamsonKevin Williamson's screenplay were described simply as "Wes CravenWes Craven will make it scary".
- Actors who auditioned for the part of Derek were asked to perform the scene in the cafeteria in which Derek sings "I Think I Love You" a cappella (without accompaniment).
- The rules for a horror-movie sequel as stated by Randy are: 1. the death total is always greater; and 2. the murder scenes are always much more elaborate, with more blood and gore. The third rule to surviving a sequel was cut from the movie, but appears in its trailer, "And number three, never, ever under any circumstance assume that the killer is dead."
- Randy's reference to fake nude pictures of Gale Weathers on the Internet was inspired by fake images of Courteney CoxCourteney Cox that appeared on the worldwide web prior to production of Scream 2. Gale says "It was Jennifer AnistonJennifer Aniston's body." Jennifer AnistonJennifer Aniston is Courteney CoxCourteney Cox's best friend in real life.
- Usually when making a motion picture when an actor is heard on screen, but not seen, such as a voice on a telephone, the actor records his part during post production, which takes place after the completion of principal photography. However, Wes CravenWes Craven had Roger JacksonRoger Jackson, The Voice, on set and actually speaking to on-screen actors by practical, not merely prop, telephone in order to create reality and fear for them. Jackson said when he was on set he was kept out of sight of other actors so they could not put a friendly face to The Voice. Jackson said also that while observing on-set action on monitors, he could see Heather GrahamHeather Graham appeared scared between takes, whereas Sarah Michelle GellarSarah Michelle Gellar would converse with him on the telephone.
- In Scream, Dewey asks Sidney, "If they make a movie about you, who's gonna play you?" Sidney answers, "With my luck, they'd cast Tori SpellingTori Spelling." In "Stab," the movie-within-a-movie of Scream 2, Tori SpellingTori Spelling plays Sidney.