| Episode List: |
| Episode Name | Disc | Disc Order | Directors | Writers | Synopsis | IMDB | Personal Rating | Diagnosis | Clinics | Medical Mystery | Solution | Overall Medicine | Soap Opera |
| Acceptance | 1 | 1 | Daniel Attias | Russel Friend
Garrett Lerner | A convict on death row suffers a massive panic attack. | 8.2 | 8 | pheochromocytoma (adrenalin releasing tumor) | woman with cancerous cough | B | B | A- | C |
| Autopsy | 1 | 2 | Deran Sarafian | Lawrence Kaplow | A 9-year old cancer patient develops symptoms unrelated to her cancer. | 8.9 | 9 | benign heart tumor and a clot in the brain | new circumcision | C | | D- | C- |
| Humpty Dumpty | 1 | 3 | Daniel Attias | Matt Witten | A hispanic handyman falls off of Cuddy's roof. | 8.1 | 8 | psitacosis (from working with roosters) | black guy don't want no racist medicine | A | A- | B+ | A- |
| TB or Not TB | 1 | 4 | Peter O'Fallon | David Foster | A medical philanthropist returns from Africa and collapses. Is it TB? | 8.1 | 8 | nesidioblastoma (insulin-secreting tumor) | woman with cat allergy / woman affraid it's breast cancer | C | | D | A- |
| Daddy's Boy | 2 | 1 | Greg Yaitanes | Thomas L. Moran | A college boy starts being shocked in his spine at a frat party. | 8.1 | 7 | radiation poisoning | flight attendant with diarrhea | A | B+ | B | B |
| Spin | 2 | 2 | Fred Gerber | Sara Hess | A cycling star collapses at a meet. | 8.0 | 7 | thymoma and myasthenia gravis | | B | C | B- | A |
| Hunting | 2 | 3 | Gloria Muzio | Liz Friedman | An HIV-positive confronts House and suddenly collapses on the street. | 8.3 | 8 | echinococcus parasite | Steve McQueen | C+ | B+ | B+ | A |
| The Mistake | 2 | 4 | David Semel | Peter Blake | Chase makes a simple mistake that leads to dire consequences. | 8.7 | 9 | liver cancer from Hepatitis C | crackly lungs and no insurance / 'Fusan' | B | B+ | B+ | B |
| Deception | 3 | 1 | Deran Sarafian | Michael R. Perry | House witnesses a woman's collapse at an off track betting parlor. | 8.5 | 8 | Munchausen's Syndrome and clostridium perfringens infection | girl on 'the jelly' | C | C | C- | C |
| Failure to Communicate | 3 | 2 | Jace Alexander | Doris Egan | A famous reporter collapses at a party in his honor. | 8.3 | 8 | malaria (from an experimental surgery in Mexico for bipolar disorder) | | B+ | C- | C- | B |
| Episode Name | Disc | Disc Order | Directors | Writers | Synopsis | IMDB | Personal Rating | Diagnosis | Clinics | Medical Mystery | Solution | Overall Medicine | Soap Opera |
| Need to Know | 3 | 3 | David Semel | Pam Davis | A busy mother begins flailing in her car. | 8.1 | 7 | combination birth control pills and fertility drugs | | A | C | B | A- |
| Distractions | 3 | 4 | Daniel Attias | Lawrence Kaplow | A teen boy has an accident and winds up with burns over large portions of his body. | 8.5 | 7 | antidepressants (to fight nicotine addiction) | House tries a migrane prevention drug | C | C | D | C- |
| Skin Deep | 4 | 1 | James Hayman | Russel Friend
Garrett Lerner
David Shore | A teen model punches another girl on the runway. | 8.6 | 8 | testical tumor and male pseudohermaphrodism | sympathetic pregnancy | B+ | A | B | B+ |
| Sex Kills | 4 | 2 | David Semel | Matt Witten | After a night of cards with daughter and other friends, a man is dropped at House's feet. | 8.6 | 7 | brucellosis (from unpasteurized sheep cheese) / gonorrhea | guy loves 'cows' | B | B | B+ | B+ |
| Clueless | 4 | 3 | Deran Sarafian | Thomas L. Moran | A swinging couple rush to the hospital after the husband's tongue swells up. | 8.4 | 7 | gold sodium thiomalate poisoning | herpes patient claims it's impossible | A | A | A | C |
| Safe | 4 | 4 | Félix Enríquez Alcalá | Peter Blake | A teenage girl suffers an allergic reaction in a clean-room. | 8.7 | 8 | tick paralysis | | B+ | C- | C | B+ |
| All In | 5 | 1 | Fred Gerber | David Foster | When a young boy is brought to the hospital, House thinks he's found his white whale. | 8.7 | 8 | Erdheim-Chester Disease | | B+ | C | B- | A |
| Sleeping Dogs Lie | 5 | 2 | Greg Yaitanes | Sara Hess | A woman brings her partner in who hasn't slept in days. | 8.3 | 7 | bubonic plague | Asian woman with stupid American child syndrome | B+ | B+ | B | A |
| House vs. God | 5 | 3 | John F. Showalter | Doris Egan | A case involving a teen faith healer inspires a unique contest between earthly and heavenly medicine. | 8.4 | 7 | herpes encephalitis | | B | B+ | B | A |
| Euphoria: Part 1 | 5 | 4 | Deran Sarafian | Matthew V. Lewis
Sara Hess | A cop comes in after an attack of giddiness. | 8.8 | 8 | naegleria | | see below | see below | see below | see below |
| Episode Name | Disc | Disc Order | Directors | Writers | Synopsis | IMDB | Personal Rating | Diagnosis | Clinics | Medical Mystery | Solution | Overall Medicine | Soap Opera |
| Euphoria: Part 2 | 6 | 1 | Deran Sarafian | Russel Friend
Garrett Lerner
David Shore
Sara Hess | It's a race against time to diagnose Foreman before he dies like the cop did. | 8.9 | 9 | naegleria | kid who siezes in her car seat | A | A- | B | A |
| Forever | 6 | 2 | Daniel Sackheim | Liz Friedman
Sara Hess | It's a struggle to save a young mother and her newborn child. | 8.0 | 7 | celiac disease | | B | B+ | C- | B+ |
| Who's Your Daddy? | 6 | 3 | Martha Mitchell | Charles M. Duncan
Lawrence Kaplow
John Mankiewicz | An old friend of House's appears to have a daughter he never knew about: a Hurricane Katrina victim. | 7.7 | 7 | Zygomycosis (type of fungus) | Kid with a red discoloration on his torso | C | B+ | C- | B+ |
| No Reason | 6 | 4 | David Shore | Lawrence Kaplow
David Shore | House is shot and a swollen tongue gets more and more severe. | 9.2 | 8 | hallucination | | | | | |
